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How can my patients receive Lysodren®?

HRA Pharma Rare Diseases is committed to providing the highest level of pharmacy services through its relationship with Walgreens Specialty Pharmacy.

How to prescribe:

Call, fax or e-scribe your prescriptions to Walgreens Specialty Pharmacy.

Call: 1-800-320-2112
Fax: 1-866-889-1510
e-scribe: search Walgreens Specialty Pharmacy

Walgreens Specialty Pharmacy Prescription Form – Lysodren

How do I e-prescribe to Walgreens Specialty Pharmacy for specialty medicines?

To provide the best access possible, our central specialty pharmacies are located in key regions across the country. While some restrictions may apply, you can usually send the prescription to whichever location listed below is closest to your patient. The preferred site for Lysodren (mitotane) is the Pittsburgh central specialty location.
If you are unsure where to send a prescription to, please call us at 855-244-2555.

Walgreens Specialty Pharmacy – PENNSYLVANIA
Pittsburgh, PA
130 Enterprise Drive
Pittsburgh, PA 15275
Phone: 888-347-3416
Fax: 877-235-9807

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Hospital and Institutional orders

For hospital and institutional orders, contact  Direct Success, Inc. at
1-844-597-6373 or Distribution@DSuccess.com.

INDICATION AND IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING ON ADRENAL CRISIS IN THE SETTING OF SHOCK, SEVERE TRAUMA OR INFECTION

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LYSODREN® is an adrenal cytotoxic agent indicated for the treatment of patients with inoperable, functional or nonfunctional, adrenocortical carcinoma (ACC).

Warning/Adrenal crisis in the setting of shock, severe trauma or infection: Patients treated with LYSODREN are at increased risk for developing adrenal crisis in the setting of shock, severe trauma or infection that may lead to death.
If shock, severe trauma or infection occurs or develops, temporarily discontinue LYSODREN and administer exogenous steroids. Monitor patients closely for infections and instruct patients to contact their physician immediately if injury, infection, or any other concomitant illness occurs.

Adrenal Insufficiency and Adrenal Crisis: Temporarily withhold LYSODREN during shock; trauma, infection or adrenal insufficiency. Steroid replacement may be necessary.

Central Nervous System (CNS) Toxicity: Monitor behavioral and neurologic assessments and mitotane plasma levels at regular intervals. Mitotane plasma levels exceeding 20 mg/L are associated with a greater incidence of toxicity. Advise patients not to drive or operate hazardous machinery if experiencing CNS adverse reactions.

Ovarian Macrocysts in Premenopausal Women: Monitor pelvic ultrasound at baseline and at regular intervals. Withhold, reduce the dose, or permanently discontinue LYSODREN based on severity.

Hematologic Toxicity: Monitor complete blood counts prior to starting LYSODREN, during dose titration and as clinically indicated. Withhold, reduce the dose or permanently discontinue based on severity.

Prolonged Bleeding Time: Prolonged bleeding time has occurred in patients treated with mitotane and this should be taken into account when surgery is considered.

Embryo-Fetal Toxicity: LYSODREN can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and to use effective nonhormonal contraception.

Lactation: Advise not to breastfeed.

Hepatic Impairment: LYSODREN is not recommended for patients with severe hepatic impairment. In patients with mild to moderate hepatic impairment, monitor mitotane plasma levels frequently and modify the dosage as needed.

Renal Impairment: LYSODREN® is not recommended for patients with severe renal impairment. In patients with mild or moderate renal impairment, monitor mitotane plasma levels frequently and modify the dosage as needed.

Most common adverse reactions include: anorexia, epigastric discomfort, nausea, vomiting diarrhea, depression, dizziness, vertigo, rash, hypercholesterolemia, hypertriglyceridemia, hypothyroidism and decreased blood free testosterone in males. LYSODREN is a hazardous drug. Advise caregivers to wear disposable gloves when handling LYSODREN tablets.

Avoid concomitant use with spironolactone, certain CYP3A substrates, hormonal contraceptives and warfarin.

Please see Full Prescribing Information, including BOXED WARNING, for LYSODREN® (mitotane) tablets.

To report SUSPECTED ADVERSE REACTIONS, contact Direct Success Pharmacy, Inc. at 1-844-LYSODREN (1-844-597-6373) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Link to US Prescribing Information including Boxed Warning.

HRA Pharma Rare Diseases, 200 avenue de Paris, 92320, Chatillon, FRANCE
Tel: +33 (0) 1 40 33 94 14 / Fax: +33 (0) 1 40 33 30 87
© 2021 HRA Pharma Rare Diseases | Lysodren is a registered trademark of HRA Pharma Rare Diseases
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Last updated: Feb 2025; LYS-US-0068

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